By Rodolfo Paoletti, Dr. David Kritchevsky
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Edwards, P. , and Popjak, G. (1977). J. Biol. Chem. 252, 644. , and Nichols, A. V. (1972). Adv. Lipid Res. 10, 1. , and Nordhausen, R. (1976). Circulation 54 (Suppl. II), 94. Forte, T. , Nichols, A. , Gong, E. , and Levy, R. I. (1971a). Biochim. Biophys. Acta 248, 381. , Norum, K. , Glomset, J. , and Nichols, A. V. (1971b). / . Clin. Invest. 50, 1141. , and Breslow, J. (1976). Circulation 54, II. 46 ALAN R. TALL AND DONALD M. SMALL Fredrickson, D. S. (1966). In "The Metabolic Basis of Inherited Disease" (J.
LCAT DEFICIENCY A number of Scandinavian families have been identified who have an absence of plasma LCAT activity (Glomset and Norum, 1973). These pa tients display renal failure (associated with accumulation of lipid droplets in glomerular cells), corneal opacities, peripheral neuropathy, and hemolytic anemia (associated with a 2-fold increase in red cell membrane cholesterol/phospholipid). Their HDL fraction comprises a cholesteryl ester-deficient fraction as well as small spherical (45-60 A diameter) HDL particles.
S. (1977). Ann. Rev. Biochem. 46, 897. Goodman, D. , Smith, F. , and Dell, R. (1978). Abstracts of 32nd Annual Meeting, Council on Arteriosclerosis. American Heart Association. , Castelli, W. , Hjortland, M. , Kannel, W. , and Dawber, T. R. (1977). Ann. Intern. Med. 87, 393. Green, P. H. , Tall, A. , and Glickman, R. M. (1978). J. Clin. Invest. 61, 528. Green, P. H. , Glickman, R. , and Tall, A. R. (1979). J. Clin. Invest. 64, 233. Grundy, S. , Ahrens, E. , and Davignon, J. (1969). J. Lipid Res.
Advances in lipid research. Vol. 17 by Rodolfo Paoletti, Dr. David Kritchevsky